After witnessing his mother's death at a young age, Uryuu Kamihate grew up disillusioned with the gods, dismissing faith in them as utter nonsense. Due to his beliefs, he aims to become a doctor, spending most of his time studying to enter the prestigious Kyoto University. To further his studies, Uryuu searches for a new place to take him in and get away from the noisy environment of the orphanage where he grew up. Chidori Amagami, head priest of the Amagami Shrine, allows him to stay at the Amagami residence. However, Uryuu has to live there with Chidori's three granddaughters—Yae, Yuna, and Asahi—who serve as shrine maidens. Moreover, Chidori has another condition for Uryuu: he has to marry one of the sisters to ensure the shrine's future and one day inherit it. But with Uryuu's goals and outlook naturally clashing against the sisters' beliefs, this already daunting ordeal seems outright impossible.

Misuzu was branded a delinquent when a small incident left him isolated. But one day, he sees the top student, Kitahara, get surrounded by bullies and decides to help him out. That sparked Kitahara's interest in the lonely boy, but Misuzu pushes Kitahara away. "If you get involved with me, you'll get ostracized by everyone else too." But it won't take long for Misuzu's resolve to falter...

There is only one person that high school student Saito Houjou truly cannot stand—and that is his temperamental classmate, Akane Sakuramori. The two have always been on bad terms; their contrasting views and personalities only lead to endless fighting. However, everything changes when Saito's grandfather and Akane's grandmother arrange a sudden meeting and insist that the two get married! Walking down the aisle is the last thing Saito and Akane want, but they are quickly coerced into accepting the ridiculous plan and soon move into a shared house as husband and wife. Although Saito and Akane despise each other, navigating life together under the same roof may just turn their bitter hatred into everlasting love.

After graduating from high school, Natsuko Hirose starts her career as an animator. Her talent quickly flourishes, and she makes her debut as a director in no time. Her first anime becomes a massive hit, sparking a social phenomenon and earning her recognition as an up-and-coming genius director. Her next project is set to be a romantic comedy movie themed around first love! However, having never been in love herself, Natsuko struggles to understand the concept of first love, and as a result, she's unable to create the storyboard, causing the movie production to come to a standstill. One day, she passes out while working on her storyboard and wakes up in the world of her favorite childhood anime movie "A Tale of Perishing."