In a day like any other, Cao Xiao Man's brother, Xiao Bei, is stabbed by a man after defending a mysterious girl. Due to the incident, and to buy medicine for his brother, Cao Xiao Man decides to earn money in a rather strange way: cross-dressing as a girl and seducing men. When he arrives to his client's house everything seems to go as planned, but the client soon discovers that Cao Xiao Man is, in fact, a boy. He decides to put Cao Xiao Man in a game where he is turned into a girl. In order for Cao Xiao Man to go back to being a boy he needs to complete the game and find the 7 Loyalties located all over the country.

After graduating from high school, Natsuko Hirose starts her career as an animator. Her talent quickly flourishes, and she makes her debut as a director in no time. Her first anime becomes a massive hit, sparking a social phenomenon and earning her recognition as an up-and-coming genius director. Her next project is set to be a romantic comedy movie themed around first love! However, having never been in love herself, Natsuko struggles to understand the concept of first love, and as a result, she's unable to create the storyboard, causing the movie production to come to a standstill. One day, she passes out while working on her storyboard and wakes up in the world of her favorite childhood anime movie "A Tale of Perishing."

After saving the world from the destructive might of Majin Buu, Gokuu Son and his allies look forward to a well-earned rest. However, unbeknownst to them, their battle was recorded and observed by Gomah, an evil being who assumes the title of King in the Demon Realm, filling the void left behind with the death of former ruler Dabura. At Gomah's side is Degesu, the younger brother of Higashi no Kaioshin, a being who lords over the universe. Jealous of his brother's power, Degesu works alongside Gomah to steal Earth's Dragon Balls and preemptively subdue any potential future enemies. Calling upon the power of the legendary dragon Shenron, Gomah wishes for Gokuu and his friends to be reverted into children, intending to rob them of the limitless power that defeated Buu. With Earth's greatest warriors shrunken down, Gomah abducts Dende, the planet's acting god. But Gokuu refuses to be set back by his new body, working to master his younger form to fight as proficiently as he could as an adult. Joined by Kaioshin and Glorio—a mysterious but seemingly rebellious demon—Gokuu pursues Gomah to the Demon Realm in order to rescue Dende and restore his friends to their natural ages.