A 30-year-old man who dreams of becoming a wizard suddenly loses his life. Reincarnated in another world as a young child named Shion, he grows up alongside Marie, his dependable older sister who adores him. Shion eagerly anticipates using magical powers, but he discovers that the new world seemingly does not have any magic. He spends the ensuing years as a gloomy and dejected child until a mystical phenomenon at a nearby lake catches the siblings' attention and breathes life back into his magical dream. While experimenting on the peculiar light emanating from the water, Shion finally confirms that magical energy really exists. It may not be convenient for anything just yet, but Shion devotes his time to studying the anomaly, determined to uncover all the existing wonders in his quest to make magic.

One day, a corporate slave Reiji, suddenly got transported to another world. He made the best of his skills to make better potions, which earned him lots of money, and with that money, made a drugstore! An Elf who has trouble aiming with his bow? Give him some eye-drops! A Dragon who always let breathes out fire unintentionally? Don't worry, we have cough medicine for you! Reiji's new, fun, slow life as a pharmacist in a village drugstore starts now!!

Shun Asanaga is a 15-year-old junior high school student with an optimistic and bright personality. One day, he finds a mysterious crystal in the office of his father, who is a scientist and businessman. When Shun touches it, the world becomes distorted, and he is sent into the world of Endra. Emilio, a prince of the kingdom of Endra, is nearing his 16th birthday and despises the reigning king, Delzain. Since Emilio is now at the age when he can inherit the throne, he takes up a weapon and attempts revenge. However, because Emilio is too weak, he is captured by Delzain and put in prison. When Emilio is in grief, the wall of his cell becomes distorted and Shun appears from there with two goals: return to his own world, and complete Emilio's revenge. What future lies ahead for the two boys trying to survive in Endra, yet raised in two different worlds?

Since their days as students, Tsukasa Jinguuji has had incredible luck with women due to his good looks; Hinata Tachibana has had almost none, overshadowed by Jinguuji's brilliance. However, while Jinguuji has never shown interest in the opposite sex, Tachibana is always desperate for a girlfriend. Despite their polar differences, they continue to be best friends even in their thirties as salarymen. One night, the two are returning home from a mixer where Jinguuji was the center of attention as usual. In his drunken rambles, a frustrated Tachibana inadvertently wishes to become a beautiful girl with irresistible charm. As if the heavens were listening, a goddess suddenly shows herself before Jinguuji and Tachibana, transporting them to another world to defeat the Demon Lord and simultaneously granting Tachibana's desire. Tachibana—now in the body of an impossibly perfect woman—has become so attractive that even Jinguuji is captivated. Moreover, Tachibana grows aware of Jinguuji's stunning appearance, finally understanding his popularity. Before they fall in love with each other, the duo must complete their mission or risk remaining prisoners to their infatuations forever.