After two-month-old kitten Chibi-neko is abandoned by her former owners, she is found by 18-year-old Tokio. Although his mother is allergic to cats and has a great fear of them, she agrees to let him keep the kitten because she fears he is becoming too withdrawn after failing his university entrance exams. Chibi-neko soon falls in love with Tokio. In her own mind, Chibi-neko is a small human who speaks in human words, although people only ever seem to hear her meow, and she believes that all humans were once kittens like her. A stray cat tells Chibi-neko of a paradise called Cottonland, where dreams can come true.

When Isaku Senagaki was five years old, the death of her parents left her to be raised by her yakuza boss grandfather, Tasuke. Now preparing to enter high school, Isaku is determined to start fresh with an honest attempt at having a normal high school experience. All she wants is to be able to make friends and find love without being defined by her connection to the yakuza. But Isaku's dreams are thwarted when her overprotective caretaker, 26-year-old Keiya Utou, takes it upon himself to enroll in Isaku's school by bribing the school administration. While Isaku yearns for a reciprocated love, she is trapped in a one-sided infatuation with Keiya, who only sees her as the boss's granddaughter he helped raise. Her longing for a normal life becomes a constant battle, and breaking free from her heart's grip is far more challenging than it sounds, as Keiya's overprotectiveness and disregard for her boundaries make it almost impossible to move on.

The Yuzuki family, which consists of four brothers, lost their parents two years ago. Hayato, the eldest son, is a hard worker and the pillar of the family. Mikoto, the second son, is calm and collected, but he has a soft spot for his younger brother Minato, whom he adores and thinks is cute. Minato, the third son, is energetic and adores his brothers, but he is clumsy and awkward. Gakuto, the fourth son, is a studious and mature first-grader who is often referred to as a "wise man." The manga depicts the four brothers' daily lives as they navigate their family, school, and community.

Set in the 1920s, Haikara-san ga Tooru is the story of the high-spirited tomboy Benio and her relationship with a handsome half-German soldier named Shinobu. Benio is a very outgoing and athletic girl with firm ideas about being able to live her life as she wants to. When she first meets Shinobu, she dislikes him intensely, even though he manages to help her out of a series of embarrassing mishaps. She is therefore surprised when she finds out that she has been forced into an arranged marriage and that her husband-to-be is none other than Shinobu! The story then has many twists and turns, as Shinobu has to fight in the war, Benio has to wrangle with the idea of getting married, and getting along with her future in-laws and employer. Meanwhile, the great Kanto earthquake looms in the future...