Poor Shinichirou Asano has the worst of luck. His parents abandoned him and ran off to Europe. If that isn't bad enough on its own, they barely left him any money to take care of himself. In order to pay rent and keep a roof over his head, he has to work. Unfortunately, he was just fired from his last job and as a high school student, he doesn't have many other prospects. One evening, he's attacked by a centipede monster on his way home. Shinichirou is saved by a mysterious girl with a bow and arrow, who he later discovers is Sakuya Shimazu, a beautiful student who attends his school. But when he later helps an injured girl, he discovers two things. First, the injured girl isn't human at all but rather a nekomata, a two-tailed demon cat. And second, Sakuya comes from a family of exorcists, who've protected humanity from rogue monsters and spirits for generations. Because Shinichirou was responsible for releasing the nekomata, Sakuya enlists his help in recapturing the demon, but that's just the beginning of Shinichirou's relationship with Sakuya. It turns out the Shimazu family needs a housekeeper and it just so happens that Shinichirou excels at cooking and likes to clean! It may not be his dream job, but if it pays the rent and puts food on the table...

When a shapeshifting demon with a thirst for human flesh, known as "youma," arrives in Raki's village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a "Claymore," a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters. After Raki's family is killed, the Claymore saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds the Claymore, known as Clare, and decides to follow her on her journeys. As the pair travel from town to town, defeating youma along the way, more about Clare's organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore. [Written by MAL Rewrite]

"Mushi": the most basic forms of life in the world. They exist without any goals or purposes aside from simply "being." They are beyond the shackles of the words "good" and "evil." Mushi can exist in countless forms and are capable of mimicking things from the natural world such as plants, diseases, and even phenomena like rainbows. This is, however, just a vague definition of these entities that inhabit the vibrant world of Mushishi, as to even call them a form of life would be an oversimplification. Detailed information on Mushi is scarce because the majority of humans are unaware of their existence. So what are Mushi and why do they exist? This is the question that a "Mushishi," Ginko, ponders constantly. Mushishi are those who research Mushi in hopes of understanding their place in the world's hierarchy of life. Ginko chases rumors of occurrences that could be tied to Mushi, all for the sake of finding an answer. It could, after all, lead to the meaning of life itself. [Written by MAL Rewrite]

Maquia is a member of a special race called the Iorph—mystical beings who can live for hundreds of years and remain separate from the lives and daily troubles of mankind. However, Maquia has always felt lonely despite being surrounded by her people, as she was orphaned from a young age. She daydreams about the outside world, but dares not travel from her home due to the warnings of the clan's chief.

One day however, the outside world finds her, as the power-hungry kingdom of Mezarte invades her homeland. They already have what is left of the giant dragons, the Renato, under their control, and now their king wishes to add the immortality of the Iorph to his bloodline.

The humans and their Renato ravage the Iorph homeland and kill most of its inhabitants. Caught in the midst of the attack, Maquia is carried off by one of the Renato that has gone berserk. It soon dies, and she is left deserted in a forest far from home, now truly alone save for the cries of a single baby off in the distance. Maquia finds the baby in a destroyed village and decides to raise him as her own, naming him Ariel. Although she knows nothing of the human world, how to raise a child that ages much faster than her, or how to live with the smoldering loneliness inside, she is determined to make it all work somehow.

[Written by MAL Rewrite]