Anime based on a 1986 novel.

Nanako is a an inept apprentice nurse to the brilliant young Dr. Kouji. Now for some reason, Nanako is always being targeted by various elements which makes Nanako wonder if she has done anything wrong. But there are certain secrets to Nanako's past that only Dr. Kouji and his family know about.

Kaoru is a 17-year-old virgin who has an S&M fetish. He has always dreamt about an SM relationship with his childhood friend Nana, who is looked upon as perfect and is always the target of boys' eyes. Their relationship has somewhat deteriorated through the years, due to them hanging out with different people and because Kaoru is not taking his education too seriously. One day though, Kaoru's mother gives some of his S&M toys to Nana for safekeeping - Nana finds the leather one-piece that Kaoru bought and tries it on but accidentally locks herself in it and doesn't have the key! Kaoru frees her of the one-piece, but then Nana realizes she may like Kaoru's hobby more than she thought and subsequently the two of them start engaging in so-called "breathers". These breathers are intended to relieve Nana of stress, stress originating from her attempts at keeping her grades and her name perfect.

Space princess Fandora and her sidekick Que are bounty hunters in an age where warp travel has become a reality, along with space criminals. Fandora possesses the red, magic, "Jewel of Lupia" which she uses to fight with when conventional weapons are ineffective. In pursuit of space criminal Red Eye Geran, they encounter in the kingdom of Lemia a mysterious evil religious leader who has taken control from its legitimate rulers. This individual possesses a blue jewel which will unify the dimensions of the universe and start an age of peace or terror if it is conjoined with the "Jewel of Lupia." And so Fandora and he are fated to meet.